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The mastcell, director of chronic pelvic pain orchestra: implications for the gynaecologist

11/10/2010

The mastcell, director of chronic pelvic pain orchestra: implications for the the gynaecologist
Full text della lettura plenaria presentata al XIX World Congress of Gynecology and Obstetrics, organizzato dalla International Federation of Gynecology and Obstetrics (FIGO), 4-9 ottobre 2009, Cape Town, South Africa
Increasing evidence supports the prominent role of up-regulated mastcells (MC's) in the maintenance of chronic inflammation and in the shifting from nociceptive to neuropathic pain in the affected tissues, contributing to chronic pelvic pain (CPP). New therapeutic lines consider reduction of agonists and/or using drugs (“antagonists”) that can down-regulated the release of pro-inflammatory, angiogenic and neurotrophic factors from the mastcells.
Gynaecologist’ may improve CPP by understanding the pathophysiology of MCs in chronic inflammation and addressing it in a multimodal therapeutic process.

Allegati disponibili:Full text della lettura

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